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HK2 a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). The predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Genetic variations of HK2 do not appear to contribute to NIDDM. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC; Kinase, other; Mitochondrial
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: cytosol; membrane; mitochondrial outer membrane
Molecular Function: fructokinase activity; glucokinase activity; hexokinase activity; mannokinase activity; protein binding
Biological Process: apoptotic mitochondrial changes; cell glucose homeostasis; glucose transport; glycolysis
Reference #:  P52789 (UniProtKB)
Alt. Names/Synonyms: DKFZp686M1669; hexokinase 2; Hexokinase type II; Hexokinase-2; hexokinase-2, muscle; HK II; HK2; HKII; HXK2; Muscle form hexokinase
Gene Symbols: HK2
Molecular weight: 102,380 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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