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Protein Page:

NPM1 a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Oncoprotein; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; granular component; intracellular ribonucleoprotein complex; large ribosomal subunit; membrane; nuclear speck; nucleolus; nucleoplasm; nucleus; protein complex; small ribosomal subunit; spindle pole centrosome
Molecular Function: activating transcription factor binding; histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; protein N-terminus binding; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; rRNA binding; Tat protein binding; transcription coactivator activity; transcription factor binding; unfolded protein binding
Biological Process: cell aging; cell growth; cell volume homeostasis; cellular response to UV; centrosome cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of centrosome duplication; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell cycle G2/M phase transition; positive regulation of cell proliferation; positive regulation of centrosome duplication; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase activity; positive regulation of protein localization to nucleolus; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of translation; protein homooligomerization; protein localization; protein oligomerization; protein stabilization; regulation of centriole replication; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of endodeoxyribonuclease activity; regulation of transcription from RNA polymerase II promoter; response to stress; ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus; ribosomal small subunit biogenesis and assembly; ribosomal small subunit export from nucleus; ribosome assembly; rRNA export from nucleus; signal transduction; viral process
Reference #:  P06748 (UniProtKB)
Alt. Names/Synonyms: B23; MGC104254; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin/nucleoplasmin family, member 1; Numatrin
Gene Symbols: NPM1
Molecular weight: 32,575 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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