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Protein Page:
CASC3

Overview
CASC3 Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. Belongs to the CASC3 family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component: cytoplasm; nuclear membrane; nucleus; ribonucleoprotein complex
Molecular Function: enzyme binding; identical protein binding; protein binding; RNA binding; ubiquitin protein ligase binding
Biological Process: intracellular mRNA localization
Reference #:  Q8K3W3 (UniProtKB)
Alt. Names/Synonyms: Barentsz; Btz; cancer susceptibility candidate 3; Cancer susceptibility candidate gene 3 protein homolog; Casc3; mBtz; metastatic lymph node 51; Metastatic lymph node gene 51 protein homolog; MLN 51 homolog; Mln51; OTTMUSP00000006856; Protein barentsz; Protein CASC3
Gene Symbols: Casc3
Molecular weight: 75,770 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
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CASC3

Protein Structure Not Found.
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