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POLH DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Interacts with REV1. Interacts with monoubiquitinated PCNA, but not unmodified PCNA. Interacts with POLI. Belongs to the DNA polymerase type-Y family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Transferase
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytosol; nucleoplasm
Molecular Function: DNA-directed DNA polymerase activity; protein binding
Biological Process: bypass DNA synthesis; DNA repair; DNA synthesis during DNA repair; regulation of DNA repair; response to UV-C
Disease: Xeroderma Pigmentosum, Variant Type
Reference #:  Q9Y253 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase eta; FLJ16395; FLJ21978; POLH; polymerase (DNA directed), eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; XP-V; XPV
Gene Symbols: POLH
Molecular weight: 78,413 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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