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ABCC4 a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 13q32.1
Cellular Component: basolateral plasma membrane; integral component of plasma membrane; membrane; plasma membrane; platelet dense granule membrane
Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; ATPase activity, coupled to transmembrane movement of substances
Biological Process: platelet degranulation; positive regulation of smooth muscle cell proliferation; prostaglandin secretion; response to drug; response to organic cyclic compound; response to organonitrogen compound; transmembrane transport
Reference #:  O15439 (UniProtKB)
Alt. Names/Synonyms: ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MOATB; MRP/cMOAT-related ABC transporter; MRP4; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; multispecific organic anion transporter B
Gene Symbols: ABCC4
Molecular weight: 149,527 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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