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Protein Page:
ATP5C

Overview
ATP5C Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase gamma chain family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial
Chromosomal Location of Human Ortholog: 10p14
Cellular Component: extracellular exosome; membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); mitochondrion; myelin sheath
Molecular Function: ATPase activity; proton-transporting ATP synthase activity, rotational mechanism; RNA binding; transmembrane transporter activity
Biological Process: ATP biosynthetic process; cristae formation; mitochondrial ATP synthesis coupled proton transport; oxidative phosphorylation
Reference #:  P36542 (UniProtKB)
Alt. Names/Synonyms: ATP synthase gamma chain, mitochondrial; ATP synthase subunit gamma, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; ATP5C; ATP5C1; ATP5CL1; ATPG; F-ATPase gamma subunit; mitochondrial ATP synthase, gamma subunit 1
Gene Symbols: ATP5C1
Molecular weight: 32,996 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
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ATP5C

Protein Structure Not Found.
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