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Protein Page:
C9

Overview
C9 Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Extracellular matrix; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15|15 A1
Cellular Component: cytosol; extracellular space; membrane attack complex; plasma membrane
Biological Process: blood coagulation; cell killing; protein homooligomerization
Reference #:  P06683 (UniProtKB)
Alt. Names/Synonyms: C9; CO9; complement component 9; Complement component C9
Gene Symbols: C9
Molecular weight: 62,002 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
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C9

Protein Structure Not Found.
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