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ENO3 Appears to have a function in striated muscle development and regeneration. Defects in ENO3 are the cause of glycogen storage disease type 13 (GSD13). A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen- beta particles are detected on ultrastructural analysis. Belongs to the enolase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; Lyase
Chromosomal Location of Human Ortholog: 11 B3|11 43.21 cM
Cellular Component: cytosol; extracellular space; membrane; plasma membrane
Molecular Function: phosphopyruvate hydratase activity; protein heterodimerization activity; protein homodimerization activity
Biological Process: glycolysis
Reference #:  P21550 (UniProtKB)
Alt. Names/Synonyms: 2-phospho-D-glycerate hydro-lyase; Beta-enolase; Eno-3; Eno3; ENOB; Enolase 3; enolase 3, beta muscle; MSE; Muscle-specific enolase; OTTMUSP00000006349; OTTMUSP00000006350; Skeletal muscle enolase
Gene Symbols: Eno3
Molecular weight: 47,025 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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