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NR1I3 Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: androgen receptor activity; DNA binding; ligand-dependent nuclear receptor activity; transcription coactivator activity; transcription factor activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
Reference #:  Q14994 (UniProtKB)
Alt. Names/Synonyms: CAR; CAR1; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; Constitutive androstane receptor; MB67; MGC150433; MGC97144; MGC97209; NR1I3; Nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67
Gene Symbols: NR1I3
Molecular weight: 39,942 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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