Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

BKR2 a receptor for bradykinin. Bradykinin elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component: endosome; integral component of plasma membrane; plasma membrane
Molecular Function: bradykinin receptor activity; phosphoinositide phospholipase C activity; protease binding; protein binding; protein heterodimerization activity; type 1 angiotensin receptor binding
Biological Process: arachidonic acid secretion; blood circulation; cell surface receptor signaling pathway; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; regulation of vascular permeability; regulation of vasoconstriction; response to salt stress; smooth muscle contraction; transmembrane receptor protein tyrosine kinase signaling pathway; vasoconstriction; vasodilation
Reference #:  P30411 (UniProtKB)
Alt. Names/Synonyms: B2 bradykinin receptor; B2R; BDKRB2; BK-2; BK-2 receptor; BK2; BKR2; BKRB2; bradykinin receptor B2; BRB2; DKFZp686O088
Gene Symbols: BDKRB2
Molecular weight: 44,461 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB