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Merlin a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: adherens junction; apical part of cell; cell body; cleavage furrow; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; early endosome; filopodium membrane; lamellipodium; membrane; neuron projection; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: actin binding; protein binding
Biological Process: actin cytoskeleton organization; cell-cell junction organization; ectoderm development; hippocampus development; lens fiber cell differentiation; mesoderm formation; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of DNA replication; negative regulation of JAK-STAT cascade; negative regulation of MAPKKK cascade; negative regulation of protein kinase activity; negative regulation of tyrosine phosphorylation of STAT protein; odontogenesis of dentine-containing teeth; positive regulation of cell differentiation; positive regulation of stress fiber formation; regulation of apoptosis; regulation of cell cycle; regulation of gliogenesis; regulation of neural precursor cell proliferation; regulation of protein localization to nucleus; regulation of protein stability; regulation of stem cell proliferation; Schwann cell proliferation
Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
Reference #:  P35240 (UniProtKB)
Alt. Names/Synonyms: ACN; BANF; MERL; Merlin; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Neurofibromin-2; NF2; SCH; Schwannomerlin; Schwannomin
Gene Symbols: NF2
Molecular weight: 69,690 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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