Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Biological Process: actin filament organization; intracellular estrogen receptor signaling pathway; negative regulation of transcription, DNA-dependent; ossification; positive regulation of bone resorption; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to cAMP; response to glucocorticoid stimulus; transcription from mitochondrial promoter