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Protein Page:
PGC-1 beta

Overview
PGC-1 beta Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: mitochondrion; nucleus; Srb-mediator complex
Molecular Function: AF-2 domain binding; estrogen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; receptor activator activity; RNA binding; transcription factor binding
Biological Process: actin filament organization; intracellular estrogen receptor signaling pathway; negative regulation of transcription, DNA-dependent; ossification; positive regulation of bone resorption; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to cAMP; response to glucocorticoid stimulus; transcription from mitochondrial promoter
Disease: Obesity
Reference #:  Q86YN6 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C1790; ERRL1; FLJ14284; PERC; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1(beta); PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1; PGC1B; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PPARGC1; PPARGC1B; PRGC2
Gene Symbols: PPARGC1B
Molecular weight: 113,222 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
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PGC-1 beta

Protein Structure Not Found.
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