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EFNB1 a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Note: This description may include information from UniProtKB.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytoplasm; extracellular exosome; integral component of plasma membrane; membrane raft; nucleus; plasma membrane; synapse
Molecular Function: ephrin receptor binding; protein binding
Biological Process: axon guidance; cell adhesion; cell-cell signaling; embryonic pattern specification; ephrin receptor signaling pathway; neural crest cell migration; positive regulation of T cell proliferation; T cell costimulation
Disease: Craniofrontonasal Syndrome
Reference #:  P98172 (UniProtKB)
Alt. Names/Synonyms: CFND; CFNS; EFL-3; EFL3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B1; Ephrin-B1; EPLG2; LERK-2; LERK2; ligand of eph-related kinase 2; MGC8782
Gene Symbols: EFNB1
Molecular weight: 38,007 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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