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DAZL RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts. Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2. Testis specific. Belongs to the RRM DAZ family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Translation
Chromosomal Location of Human Ortholog: 3p24.3
Cellular Component: cytoplasm; intracellular; nucleus; polysome; protein complex
Molecular Function: identical protein binding; mRNA 3'-UTR binding; protein binding; RNA binding; translation activator activity
Biological Process: female meiosis II; germ cell development; multicellular organism development; oocyte maturation; positive regulation of meiosis; positive regulation of translational initiation; spermatogenesis
Reference #:  Q92904 (UniProtKB)
Alt. Names/Synonyms: DAZ homolog; DAZ-like autosomal; DAZH; DAZL; DAZL1; DAZLA; Deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like autosomal; germline specific RNA binding protein; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; SPGYLA
Gene Symbols: DAZL
Molecular weight: 33,178 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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