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XPA Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q22.33
Cellular Component: DNA replication factor A complex; intercellular bridge; nucleoplasm; nucleus
Molecular Function: damaged DNA binding; protein binding; protein domain specific binding; protein homodimerization activity
Biological Process: base-excision repair; DNA repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; transcription-coupled nucleotide-excision repair; UV protection
Disease: Xeroderma Pigmentosum, Complementation Group A
Reference #:  P23025 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-A cells; excision repair-controlling; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPA; XPAC
Gene Symbols: XPA
Molecular weight: 31,368 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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