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WASP a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: actin cytoskeleton; actin filament; cytosol
Molecular Function: GTPase regulator activity; identical protein binding; phospholipase binding; protein binding; protein kinase binding; Rac GTPase binding; SH3 domain binding; small GTPase binding
Biological Process: actin polymerization and/or depolymerization; blood coagulation; Cdc42 protein signal transduction; defense response; epidermis development; immune response; negative regulation of stress fiber formation; protein complex assembly; regulation of actin polymerization and/or depolymerization; regulation of stress fiber formation; regulation of T cell antigen processing and presentation; Rho protein signal transduction; T cell receptor signaling pathway
Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1
Reference #:  P42768 (UniProtKB)
Alt. Names/Synonyms: IMD2; THC; THC1; thrombocytopenia 1 (X-linked); WAS; WASp; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); Wiskott-Aldrich syndrome protein
Gene Symbols: WAS
Molecular weight: 52,913 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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