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Protein Page:

FBW1B a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: centrosome; cytosol; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function: protein binding; protein dimerization activity; ubiquitin-protein transferase activity
Biological Process: G2/M transition of mitotic cell cycle; negative regulation of NF-kappaB import into nucleus; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-templated; post-translational protein modification; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; rhythmic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; Wnt signaling pathway
Reference #:  Q9UKB1 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat-containing protein 2; BTRC2; BTRCP2; F-box and WD repeat domain containing 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Fbw11; FBW1B; FBXW11; FBXW1B; Homologous to Slimb protein; HOS; KIAA0696
Gene Symbols: FBXW11
Molecular weight: 62,091 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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