Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
ADAMTS12

Overview
ADAMTS12 Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p13.3-p13.2
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase activity; protein binding; zinc ion binding
Biological Process: cell migration; cell-matrix adhesion; negative regulation of chondrocyte differentiation; proteoglycan catabolic process; proteolysis involved in cellular protein catabolic process; regulation of inflammatory response
Reference #:  P58397 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; ADAM metallopeptidase with thrombospondin type 1 motif, 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12; ADAMTS12; ATS12; PRO4389
Gene Symbols: ADAMTS12
Molecular weight: 177,676 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Select Structure to View Below

ADAMTS12

Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB