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Protein Page:

SNCA a member of the synuclein family that is abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Aggregated forms of the protein are implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Three alternatively spliced human isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: actin cytoskeleton; axon; cell cortex; cell junction; cell soma; cytoplasm; cytosol; extracellular region; extracellular space; Golgi apparatus; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; postsynapse; ribosome; rough endoplasmic reticulum; synaptic vesicle; terminal bouton
Molecular Function: alpha-tubulin binding; beta-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; fatty acid binding; ferrous iron binding; histone binding; Hsp70 protein binding; identical protein binding; kinesin binding; magnesium ion binding; microtubule binding; oxidoreductase activity; phospholipase binding; phospholipid binding; phosphoprotein binding; protein binding; protein domain specific binding; protein N-terminus binding; tau protein binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; adult locomotory behavior; aging; apoptosis; behavioral response to cocaine; calcium ion homeostasis; cellular protein metabolic process; cellular response to copper ion; cellular response to epinephrine stimulus; cellular response to fibroblast growth factor stimulus; cellular response to oxidative stress; dopamine biosynthetic process; dopamine uptake; excitatory postsynaptic potential; fatty acid metabolic process; microglial cell activation; mitochondrial membrane organization and biogenesis; negative regulation of apoptosis; negative regulation of chaperone-mediated autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dopamine metabolic process; negative regulation of dopamine uptake involved in synaptic transmission; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of neuron apoptosis; negative regulation of neuron death; negative regulation of norepinephrine uptake; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein phosphorylation; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; neutral lipid metabolic process; organelle ATP synthesis coupled electron transport; phospholipid metabolic process; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of inflammatory response; positive regulation of neuron death; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; regulation of phospholipase activity; regulation of presynapse assembly; response to drug; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synapse organization; synaptic vesicle endocytosis
Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant
Reference #:  P37840 (UniProtKB)
Alt. Names/Synonyms: Alpha-synuclein; alpha-synuclein, isoform NACP140; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; synuclein, alpha (non A4 component of amyloid precursor); SYUA
Gene Symbols: SNCA
Molecular weight: 14,460 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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