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RAC1 a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: actin filament; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendritic spine; endoplasmic reticulum membrane; extracellular exosome; extracellular matrix; focal adhesion; Golgi membrane; lamellipodium; melanosome; membrane; plasma membrane; secretory granule membrane; trans-Golgi network
Molecular Function: ATPase binding; enzyme binding; GTP binding; GTPase activity; histone deacetylase binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; Rab GTPase binding; Rho GDP-dissociation inhibitor binding; thioesterase binding
Biological Process: actin cytoskeleton organization; actin filament polymerization; anatomical structure morphogenesis; blood coagulation; bone resorption; cell adhesion; cell motility; cell proliferation; cell-matrix adhesion; ephrin receptor signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; G-protein coupled receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; inflammatory response; lamellipodium assembly; localization within membrane; mast cell chemotaxis; negative regulation of interleukin-23 production; negative regulation of receptor-mediated endocytosis; neutrophil degranulation; platelet activation; positive regulation of apoptosis; positive regulation of cell-substrate adhesion; positive regulation of DNA replication; positive regulation of focal adhesion assembly; positive regulation of lamellipodium assembly; positive regulation of microtubule polymerization; positive regulation of neutrophil chemotaxis; positive regulation of protein phosphorylation; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; positive regulation of substrate adhesion-dependent cell spreading; protein amino acid phosphorylation; Rac protein signal transduction; regulation of cell migration; regulation of cell size; regulation of defense response to virus by virus; regulation of hydrogen peroxide metabolic process; regulation of lamellipodium assembly; regulation of small GTPase mediated signal transduction; regulation of stress fiber assembly; response to wounding; ruffle organization; semaphorin-plexin signaling pathway; T cell costimulation; vascular endothelial growth factor receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Mental Retardation, Autosomal Dominant 48
Reference #:  P63000 (UniProtKB)
Alt. Names/Synonyms: Cell migration-inducing gene 5 protein; MGC111543; MIG5; migration-inducing gene 5; p21-Rac1; RAC1; Ras-like protein TC25; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1; TC-25; TC25
Gene Symbols: RAC1
Molecular weight: 21,450 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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