Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
PTEN

Overview
PTEN a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Phosphatase, lipid; Tumor suppressor
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: apical plasma membrane; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; extracellular region; mitochondrion; neuron projection; nucleoplasm; nucleus; plasma membrane; PML body; postsynaptic membrane
Molecular Function: anaphase-promoting complex binding; enzyme binding; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; ionotropic glutamate receptor binding; lipid binding; magnesium ion binding; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; platelet-derived growth factor receptor binding; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; ubiquitin-specific protease binding
Biological Process: adult behavior; aging; angiogenesis; apoptosis; brain morphogenesis; cardiac muscle tissue development; cell migration; cell proliferation; cellular response to ethanol; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to leptin stimulus; central nervous system development; central nervous system myelin maintenance; central nervous system neuron axonogenesis; dentate gyrus development; endothelial cell migration; forebrain morphogenesis; heart development; inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning and/or memory; locomotor rhythm; locomotory behavior; male mating behavior; maternal behavior; memory; multicellular organismal response to stress; negative regulation of apoptosis; negative regulation of axon regeneration; negative regulation of axonogenesis; negative regulation of cardiac muscle cell proliferation; negative regulation of cell aging; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of excitatory postsynaptic potential; negative regulation of focal adhesion assembly; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of keratinocyte migration; negative regulation of myelination; negative regulation of organ growth; negative regulation of phagocytosis; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein kinase B signaling cascade; negative regulation of protein phosphorylation; negative regulation of receptor activity; negative regulation of ribosome biogenesis; negative regulation of synaptic vesicle clustering; nerve-nerve synaptic transmission; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of transcription factor activity; positive regulation of ubiquitin protein ligase activity; prepulse inhibition; protein amino acid dephosphorylation; protein deubiquitination; protein kinase B signaling; protein stabilization; regulation of B cell apoptotic process; regulation of cellular component size; regulation of cyclin-dependent protein kinase activity; regulation of myeloid cell apoptosis; regulation of neuron projection development; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to activity; response to arsenic; response to ATP; response to drug; response to estradiol; response to glucose stimulus; response to nutrient; response to zinc ion; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; Wnt receptor signaling pathway through beta-catenin
Disease: Bannayan-riley-ruvalcaba Syndrome; Cowden Syndrome 1; Endometrial Cancer; Glioma Susceptibility 2; Macrocephaly/autism Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Meningioma, Familial, Susceptibility To; Prostate Cancer; Squamous Cell Carcinoma, Head And Neck; Thyroid Carcinoma, Follicular; Vacterl Association With Hydrocephalus
Reference #:  P60484 (UniProtKB)
Alt. Names/Synonyms: 10q23del; BZS; DEC; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN; PTEN1; TEP1
Gene Symbols: PTEN
Molecular weight: 47,166 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTEN

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA