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TMED9 Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. Belongs to the EMP24/GP25L family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; trans-Golgi network transport vesicle; transport vesicle
Molecular Function: protein binding; syntaxin binding
Biological Process: COPI coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; protein exit from endoplasmic reticulum; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q9BVK6 (UniProtKB)
Alt. Names/Synonyms: Glycoprotein 25L2; GP25L2; gp25L2 protein; HSGP25L2G; TMED9; Transmembrane emp24 domain-containing protein 9; transmembrane emp24 protein transport domain containing 9
Gene Symbols: TMED9
Molecular weight: 27,277 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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