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AP1S3 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: clathrin-coated pit; cytoplasmic vesicle membrane; cytosol; Golgi membrane; intracellular membrane-bound organelle; lysosomal membrane; membrane coat; trans-Golgi network membrane
Molecular Function: protein binding; protein transporter activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; protein targeting; regulation of defense response to virus by virus; vesicle-mediated transport
Disease: Psoriasis 15, Pustular, Susceptibility To
Reference #:  Q96PC3 (UniProtKB)
Alt. Names/Synonyms: Adapter-related protein complex 1 sigma-1C subunit; Adaptor protein complex AP-1 sigma-1C subunit; adaptor-related protein complex 1, sigma 3 subunit; AP-1 complex subunit sigma-3; AP1S3; Clathrin assembly protein complex 1 sigma-1C small chain; Golgi adaptor HA1/AP1 adaptin sigma-1C subunit; sigma 1C adaptin; Sigma 1C subunit of AP-1 clathrin; Sigma-adaptin 1C; Sigma1C-adaptin
Gene Symbols: AP1S3
Molecular weight: 18,280 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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