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CISD2 a single-pass membrane protein of the endoplasmic reticulum that regulates autophagy. Has also been reported to localize to the mitochondrion outer membrane. Antagonizes ATG6-mediated cellular autophagy. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. Directly interacts with BCL2; the interaction is disrupted by BIK interaction with BCL2. It has been reported to mainly localizes to the mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome 2 (WFS2), is a rare autosomal recessive disorder characterized by optic atrophy and diabetes mellitus. Other symptoms include the presence of profound upper gastrointestinal ulceration, significant bleeding tendency, defective platelet aggregation with collagen and various neurological symptoms. Initially thought to be a zinc-finger protein, it was later shown to bind 1 2Fe-2S cluster instead. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane; mitochondrial outer membrane; protein complex
Molecular Function: 2 iron, 2 sulfur cluster binding; metal ion binding; protein binding; protein homodimerization activity; RNA binding
Biological Process: mitochondrion degradation; multicellular organismal aging; regulation of autophagy
Disease: Wolfram Syndrome 2
Reference #:  Q8N5K1 (UniProtKB)
Alt. Names/Synonyms: CDGSH iron sulfur domain 2; CDGSH iron sulfur domain-containing protein 2; CDGSH2; CISD2; Endoplasmic reticulum intermembrane small protein; ERIS; Miner1; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Nutrient-deprivation autophagy factor-1; WFS2; ZCD2; zinc finger, CDGSH-type domain 2
Gene Symbols: CISD2
Molecular weight: 15,278 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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