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nNOS nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q24.22
Cellular Component: caveola; cytoplasm; cytoskeleton; cytosol; dendritic spine; membrane raft; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; protein complex; ryanodine receptor complex; sarcolemma; sarcoplasmic reticulum; synapse; T-tubule; Z disc
Molecular Function: arginine binding; cadmium ion binding; calmodulin binding; FAD binding; FMN binding; heme binding; ion channel binding; iron ion binding; NADP binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; protein binding; sodium channel regulator activity; tetrahydrobiopterin binding
Biological Process: arginine catabolic process; cell redox homeostasis; cellular response to growth factor stimulus; exogenous drug catabolic process; multicellular organismal response to stress; myoblast fusion; negative regulation of adrenergic receptor signaling pathway involved in heart process; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of calcium ion transport into cytosol; negative regulation of hydrolase activity; negative regulation of potassium ion transport; negative regulation of serotonin uptake; neurotransmitter biosynthetic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of adrenergic receptor signaling pathway involved in heart process; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of neurogenesis; regulation of sodium ion transport; response to heat; response to hypoxia; retrograde trans-synaptic signaling by nitric oxide; striated muscle contraction; vasodilation
Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
Reference #:  P29475 (UniProtKB)
Alt. Names/Synonyms: bNOS; Constitutive NOS; IHPS1; N-NOS; NC-NOS; Neuronal NOS; nitric oxide synthase 1 (neuronal); Nitric oxide synthase, brain; nNOS; NOS; NOS type I; NOS1
Gene Symbols: NOS1
Molecular weight: 160,970 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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