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NFkB-p65 a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. P65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Three splice-variant isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleolus; nucleoplasm; nucleus; transcription factor complex
Molecular Function: actinin binding; activating transcription factor binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA binding transcription factor activity; histone deacetylase binding; identical protein binding; NF-kappaB binding; phosphate binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein N-terminus binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding
Biological Process: acetaldehyde metabolic process; aging; cellular defense response; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to nicotine; cellular response to peptide hormone stimulus; cellular response to tumor necrosis factor; cytokine-mediated signaling pathway; defense response to virus; Fc-epsilon receptor signaling pathway; hair follicle development; inflammatory response; liver development; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleotide-binding oligomerization domain containing 2 signaling pathway; organ morphogenesis; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon type I production; positive regulation of interleukin-12 biosynthetic process; positive regulation of miRNA metabolic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of Schwann cell differentiation; positive regulation of T cell receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription, DNA-templated; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription, DNA-templated; response to amino acid; response to cAMP; response to cobalamin; response to drug; response to insulin stimulus; response to morphine; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to progesterone; response to UV-B; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway; viral process
Reference #:  Q04206 (UniProtKB)
Alt. Names/Synonyms: MGC131774; NFKB3; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65; RELA; TF65; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)); v-rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
Gene Symbols: RELA
Molecular weight: 60,219 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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