Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

NFkB-p105 a transcription factor of the nuclear factor-kappaB ( NFkB) group. Undergoes cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of NFkB. NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: cytoplasm; cytosol; extracellular region; mitochondrion; nucleoplasm; nucleus; secretory granule lumen
Molecular Function: actinin binding; chromatin binding; DNA binding transcription factor activity; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription factor binding; transcription regulatory region DNA binding
Biological Process: apoptosis; cellular response to dsRNA; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to nicotine; cellular response to peptide hormone stimulus; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of calcidiol 1-monooxygenase activity; negative regulation of cellular protein metabolic process; negative regulation of cholesterol transport; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vitamin D biosynthetic process; neutrophil degranulation; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; positive regulation of hyaluronan biosynthetic process; positive regulation of interferon type I production; positive regulation of lipid storage; positive regulation of macrophage derived foam cell differentiation; positive regulation of miRNA metabolic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; response to muscle stretch; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transcription from RNA polymerase II promoter
Disease: Immunodeficiency, Common Variable, 12
Reference #:  P19838 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C01211; DNA binding factor KBF1; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFKB1; nuclear factor kappa-B DNA binding subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50
Gene Symbols: NFKB1
Molecular weight: 105,356 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein