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Protein Page:

POLE Participates in DNA repair and in chromosomal DNA replication. Belongs to the DNA polymerase type-B family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA replication; EC; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 12q24.33
Cellular Component: epsilon DNA polymerase complex; nucleoplasm; nucleus; plasma membrane
Molecular Function: 4 iron, 4 sulfur cluster binding; chromatin binding; DNA binding; DNA-directed DNA polymerase activity; nucleotide binding; protein binding; single-stranded DNA specific 3'-5'exodeoxyribonuclease activity; zinc ion binding
Biological Process: base-excision repair, gap-filling; DNA replication; DNA replication initiation; DNA replication proofreading; DNA synthesis involved in DNA repair; embryonic organ development; G1/S transition of mitotic cell cycle; leading strand elongation; nucleotide-excision repair, DNA gap filling; telomere maintenance via semi-conservative replication
Disease: Colorectal Cancer, Susceptibility To, 12; Facial Dysmorphism, Immunodeficiency, Livedo, And Short Stature
Reference #:  Q07864 (UniProtKB)
Alt. Names/Synonyms: DKFZp434F222; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A; DPOE1; FLJ21434; POLE; POLE1; polymerase (DNA directed), epsilon
Gene Symbols: POLE
Molecular weight: 261,518 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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