a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Molecular Function: ATP binding; enzyme binding; magnesium ion binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process: activation of JNK activity; apoptosis; Fc-epsilon receptor signaling pathway; JNK cascade; peptidyl-tyrosine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; regulation of apoptosis; regulation of mitotic cell cycle; response to heat; response to osmotic stress; response to tumor necrosis factor; response to UV; signal transduction; stress-activated MAPK cascade