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MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ATP binding; enzyme binding; magnesium ion binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process: activation of JNK activity; apoptosis; Fc-epsilon receptor signaling pathway; JNK cascade; peptidyl-tyrosine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; regulation of apoptosis; regulation of mitotic cell cycle; response to heat; response to osmotic stress; response to tumor necrosis factor; response to UV; signal transduction; stress-activated MAPK cascade
Reference #:  O14733 (UniProtKB)
Alt. Names/Synonyms: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; JNKK2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MEK7; mitogen-activated protein kinase kinase 7; MKK7; MP2K7; PRKMK7
Gene Symbols: MAP2K7
Molecular weight: 47,485 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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