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MEF2A a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription factor activity
Biological Process: dendrite morphogenesis; heart development; MAPKKK cascade; mitochondrial genome maintenance; mitochondrion distribution; negative regulation of transcription from RNA polymerase II promoter; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac myofibril development
Disease: Coronary Artery Disease, Autosomal Dominant, 1
Reference #:  Q02078 (UniProtKB)
Alt. Names/Synonyms: ADCAD1; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); MEF2; MEF2A; myocyte enhancer factor 2A; Myocyte-specific enhancer factor 2A; RSRFC4; RSRFC9; Serum response factor-like protein 1
Gene Symbols: MEF2A
Molecular weight: 54,811 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  ErbB/HER Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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