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Protein Page:

MDM2 a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 via Akt-mediated MDM2 phosphorylation. Phosphorylation of MDM2 increases its interaction with p300, providing a platform to allow the assembly of the protein complex necessary for MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. Facilitates the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Eight alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Inhibitor; Ligase; Nucleolus; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: cytoplasm; cytosol; nuclear body; nucleolus; nucleoplasm; nucleus; plasma membrane; protein complex
Molecular Function: 5S rRNA binding; enzyme binding; identical protein binding; ligase activity; p53 binding; protein binding; protein N-terminus binding; ribonucleoprotein binding; SUMO ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; establishment of protein localization; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; peptidyl-lysine modification; positive regulation of cell proliferation; positive regulation of mitotic cell cycle; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein complex assembly; protein destabilization; protein deubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; proteolysis involved in cellular protein catabolic process; regulation of protein catabolic process; response to antibiotic
Disease: Accelerated Tumor Formation, Susceptibility To
Reference #:  Q00987 (UniProtKB)
Alt. Names/Synonyms: Double minute 2 protein; double minute 2, human homolog of; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; MDM2; Mdm2 p53 binding protein homolog (mouse); Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; Oncoprotein Mdm2; p53-binding protein; p53-binding protein Mdm2; ubiquitin-protein ligase E3 Mdm2
Gene Symbols: MDM2
Molecular weight: 55,233 Da
Basal Isoelectric point: 4.6  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G2/M DNA Damage Checkpoint  |  PI3K/Akt Signaling
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Protein Structure Not Found.
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