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IGBP1 Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytosol
Molecular Function: protein binding; protein phosphatase 2A binding; protein phosphatase regulator activity
Biological Process: negative regulation of caspase activity; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; regulation of dephosphorylation
Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia
Reference #:  P78318 (UniProtKB)
Alt. Names/Synonyms: ALPHA-4; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ); CD79a-binding protein 1; IBP1; IGBP1; immunoglobulin (CD79A) binding protein 1; immunoglobulin binding protein 1; Immunoglobulin-binding protein 1; Protein alpha-4; protein phosphatase 2A, regulatory subunit alpha-4; Renal carcinoma antigen NY-REN-16
Gene Symbols: IGBP1
Molecular weight: 39,222 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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