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MARCKS the most prominent cellular substrate of protein kinase C. Binds calmodulin, actin, and synapsin. A filamentous actin cross-linking protein. Critical for normal brain development. Phosphorylation by PKC displaces it from the plasma membrane, inhibiting F-actin cross-linking activity. Plays a role in growth cone adhesion: its nonphosphorylated form stabilizes integrin-mediated adhesions, and its phosphorylation-triggered release from adhesions causes localized growth cone detachment. Highly expressed in immature T and B lymphocytes: its expression is highest in CD4-8- T cells and B-cell blasts generated by antigen receptor signaling. Its expression and phosphorylation are closely linked to microglial activation processes involved in pathological conditions such as neuroinflammation and neurodegeneration. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: actin cytoskeleton; focal adhesion; plasma membrane
Biological Process: regulation of insulin secretion
Reference #:  P29966 (UniProtKB)
Alt. Names/Synonyms: 80K-L; 80K-L protein; FLJ14368; FLJ90045; MACS; MARCKS; MARCS; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; PKCSL; PRKCSL; Protein kinase C substrate, 80 kDa protein, light chain
Gene Symbols: MARCKS
Molecular weight: 31,555 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
CST Pathways:  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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