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MALT1 Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 18q21.32
Cellular Component: cytoplasm; cytosol; fibrillar center; nucleolus; nucleus; plasma membrane; protein complex
Molecular Function: kinase activator activity; peptidase activity; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of T cell activation; positive regulation of T cell cytokine production; protein oligomerization; proteolysis; regulation of apoptosis; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway
Disease: Immunodeficiency 12
Reference #:  Q9UDY8 (UniProtKB)
Alt. Names/Synonyms: caspase-like protein; DKFZp434L132; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MALT1; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase
Gene Symbols: MALT1
Molecular weight: 92,272 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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