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LAT an adaptor protein involved in T-cell antigen receptor (TCR) signal transduction pathway. Plays an important role downstream of protein tyrosine kinases. Essential for TCR-mediated Ras-Erk activation and calcium flux. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: immunological synapse; integral to membrane; lipid raft; plasma membrane; signalosome
Molecular Function: protein binding; protein kinase binding; Ras guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity
Biological Process: calcium-mediated signaling; immune response; integrin-mediated signaling pathway; MAPKKK cascade; platelet activation; positive regulation of protein kinase activity; Ras protein signal transduction; regulation of T cell activation; T cell activation; T cell receptor signaling pathway
Disease: Erythrokeratodermia Variabilis Et Progressiva 2; Immunodeficiency 52
Reference #:  O43561 (UniProtKB)
Alt. Names/Synonyms: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; LAT; LAT1; linker for activation of T cells; Linker for activation of T-cells family member 1; p36-38; pp36
Gene Symbols: LAT
Molecular weight: 27,930 Da
Basal Isoelectric point: 4.27  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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