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TAX1BP1 Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: cytosol
Molecular Function: kinase binding; protein binding
Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of interferon type I production
Reference #:  Q86VP1 (UniProtKB)
Alt. Names/Synonyms: CALCOCO3; T6BP; Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1-binding protein 1; TAX1BP1; TAXB1; TRAF6-binding protein; TXBP151
Gene Symbols: TAX1BP1
Molecular weight: 90,877 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
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