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IkB-alpha a regulatory protein that inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Inhibitor
Chromosomal Location of Human Ortholog: 14q13.2
Cellular Component: cytoplasm; cytosol; intracellular; nucleus; plasma membrane
Molecular Function: enzyme binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; apoptosis; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; negative regulation of apoptosis; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway
Disease: Ectodermal Dysplasia, Anhidrotic, With T-cell Immunodeficiency, Autosomal Dominant
Reference #:  P25963 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; MAD-3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Symbols: NFKBIA
Molecular weight: 35,609 Da
Basal Isoelectric point: 4.57  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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