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hnRNP K a heterogeneous nuclear ribonucleoprotein (hnRNP). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 9q21.32
Cellular Component: extracellular matrix; focal adhesion; membrane; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: cadherin binding; protein binding; protein domain specific binding; RNA binding; single-stranded DNA binding
Biological Process: negative regulation of apoptosis; nuclear mRNA splicing, via spliceosome; positive regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of receptor-mediated endocytosis; positive regulation of transcription from RNA polymerase II promoter; RNA metabolic process; RNA processing; signal transduction
Disease: Au-kline Syndrome
Reference #:  P61978 (UniProtKB)
Alt. Names/Synonyms: CSBP; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; HNRNPK; HNRPK; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP
Gene Symbols: HNRNPK
Molecular weight: 50,976 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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