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Protein Page:

HDAC5 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; nuclear speck; nucleoplasm; nucleus
Molecular Function: histone deacetylase activity; histone deacetylase binding; protein binding; protein deacetylase activity; protein kinase C binding; transcription factor binding
Biological Process: B cell activation; B cell differentiation; chromatin remodeling; chromatin silencing; establishment and/or maintenance of chromatin architecture; histone deacetylation; inflammatory response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid deacetylation; regulation of gene expression, epigenetic; regulation of protein binding
Reference #:  Q9UQL6 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-9; FLJ90614; HD5; HDAC5; Histone deacetylase 5; KIAA0600; NY-CO-9
Gene Symbols: HDAC5
Molecular weight: 121,978 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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