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Protein Page:

HDAC4 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; cytosol; histone deacetylase complex; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: histone deacetylase activity; histone deacetylase binding; potassium ion binding; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription activator binding; transcription factor binding; zinc ion binding
Biological Process: B cell activation; B cell differentiation; cardiac muscle hypertrophy; chromatin remodeling; histone deacetylation; inflammatory response; negative regulation of glycolysis; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; positive regulation of cell proliferation; positive regulation of protein sumoylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid deacetylation; regulation of gene expression, epigenetic; regulation of protein binding; response to denervation involved in regulation of muscle adaptation
Reference #:  P56524 (UniProtKB)
Alt. Names/Synonyms: HA6116; HD4; HDAC-A; HDAC4; HDACA; Histone deacetylase 4; histone deacetylase A; KIAA0288
Gene Symbols: HDAC4
Molecular weight: 119,040 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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