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H4 histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The gene encoding H4 is intronless. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component: extracellular matrix; extracellular region; membrane; nuclear chromosome; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleus; protein complex
Molecular Function: DNA binding; histone binding; protein binding; protein domain specific binding; RNA binding
Biological Process: cellular protein metabolic process; chromatin silencing at rDNA; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; double-strand break repair via nonhomologous end joining; negative regulation of gene expression, epigenetic; negative regulation of megakaryocyte differentiation; nucleosome assembly; positive regulation of gene expression, epigenetic; protein heterotetramerization; telomere capping; telomere organization and biogenesis
Reference #:  P62805 (UniProtKB)
Alt. Names/Synonyms: H4; H4 histone family, member A; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; histone 1, H4a; histone cluster 1, H4a; Histone H4
Gene Symbols: HIST1H4A
Molecular weight: 11,236 Da
Basal Isoelectric point: 11.36  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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