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Protein Page:

RASGRF1 a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 9 E3.1|9 47.31 cM
Cellular Component: apicolateral plasma membrane; basolateral plasma membrane; cell soma; cytoplasm; cytosol; growth cone
Molecular Function: glutamate receptor binding; protein binding; protein C-terminus binding; protein kinase binding; Ras GTPase binding; receptor tyrosine kinase binding
Biological Process: cell proliferation; neurite development; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; regulation of neuronal synaptic plasticity; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of synaptic plasticity
Reference #:  P27671 (UniProtKB)
Alt. Names/Synonyms: AI844718; Cdc25; CDC25Mm; GNRP; GRF beta; Grf1; Grfbeta; guanine nucleotide releasing factor 1; Guanine nucleotide-releasing protein; p190; P190-A; p190RhoGEF; Ras guanine release factor beta; RAS protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; Rasgrf1; RGRF1
Gene Symbols: Rasgrf1
Molecular weight: 144,102 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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