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FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: Autophagy; DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; chromatin DNA binding; DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity
Biological Process: anatomical structure morphogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; regulation of translation; tumor necrosis factor-mediated signaling pathway
Reference #:  O43524 (UniProtKB)
Alt. Names/Synonyms: AF6q21; AF6q21 protein; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3; FOXO3A; MGC12739; MGC31925
Gene Symbols: FOXO3
Molecular weight: 71,277 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  G1/S Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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