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Protein Page:

FOXO1A a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 13q14.11
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; chromatin binding; protein binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding
Biological Process: anatomical structure morphogenesis; cell differentiation; cell glucose homeostasis; cellular response to insulin stimulus; cellular response to starvation; endocrine pancreas development; fat cell differentiation; insulin receptor signaling pathway; negative regulation of apoptosis; negative regulation of fat cell differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid acetylation; response to DNA damage stimulus; thermoregulation
Disease: Rhabdomyosarcoma 2
Reference #:  Q12778 (UniProtKB)
Alt. Names/Synonyms: FKH1; FKHR; forkhead box O1; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; forkhead homolog in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1; FOXO1A
Gene Symbols: FOXO1
Molecular weight: 69,662 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  G1/S Checkpoint  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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