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Ezrin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell projection; cortical cytoskeleton; cytoplasm; cytosol; endosome; extracellular space; extrinsic to membrane; fibrillar center; filopodium; focal adhesion; immunological synapse; membrane; microvillus; perinuclear region of cytoplasm; plasma membrane; ruffle; vesicle
Molecular Function: actin binding; actin filament binding; ATPase binding; cadherin binding; cell adhesion molecule binding; microtubule binding; protein binding; protein domain specific binding; RNA binding
Biological Process: actin cytoskeleton reorganization; actin filament bundle formation; astral microtubule organization and biogenesis; axon guidance; cortical microtubule organization and biogenesis; establishment of centrosome localization; establishment of epithelial cell polarity; filopodium formation; gland morphogenesis; leukocyte adhesion; membrane to membrane docking; microvillus biogenesis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; positive regulation of protein secretion; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of cell size
Reference #:  P15311 (UniProtKB)
Alt. Names/Synonyms: CVIL; CVL; Cytovillin; cytovillin 2; DKFZp762H157; EZR; EZRI; Ezrin; FLJ26216; MGC1584; p81; VIL2; villin 2 (ezrin); Villin-2
Gene Symbols: EZR
Molecular weight: 69,413 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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