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ER-alpha a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 6q25.1-q25.2
Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; protein complex
Molecular Function: ATPase binding; beta-catenin binding; chromatin binding; enzyme binding; estrogen receptor activity; estrogen receptor binding; estrogen response element binding; identical protein binding; protein binding; protein kinase binding; steroid binding; steroid hormone receptor activity; TATA-binding protein binding; transcription factor binding
Biological Process: elevation of cytosolic calcium ion concentration; estrogen receptor signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcriptional preinitiation complex assembly; protein deubiquitination; regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; response to estrogen stimulus; signal transduction; steroid hormone receptor signaling pathway; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Breast Cancer; Estrogen Resistance; Migraine With Or Without Aura, Susceptibility To, 1; Myocardial Infarction, Susceptibility To
Reference #:  P03372 (UniProtKB)
Alt. Names/Synonyms: DKFZp686N23123; ER; ER-alpha; Era; ESR; ESR1; ESRA; Estradiol receptor; Estrogen receptor; estrogen receptor 1; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; NR3A1; Nuclear receptor subfamily 3 group A member 1
Gene Symbols: ESR1
Molecular weight: 66,216 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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