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IQGAP2 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component: actin cytoskeleton; cell surface; cytoplasm; cytosol; filamentous actin; filopodium; lamellipodium; plasma membrane; secretory granule membrane
Molecular Function: actin binding; actin filament binding; GTPase inhibitor activity; phosphatidylinositol-3,4,5-triphosphate binding; Rac GTPase binding; Rho GTPase binding
Biological Process: neutrophil degranulation; signal transduction
Reference #:  Q13576 (UniProtKB)
Alt. Names/Synonyms: IQ motif containing GTPase activating protein 2; IQGA2; IQGAP2; Ras GTPase-activating-like protein IQGAP2
Gene Symbols: IQGAP2
Molecular weight: 180,578 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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