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SHMT2 Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; Energy Metabolism - methane; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: cytoplasm; microtubule cytoskeleton; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleus
Molecular Function: chromatin binding; glycine hydroxymethyltransferase activity; protein binding; pyridoxal phosphate binding
Biological Process: folic acid metabolic process; glycine metabolic process; L-serine metabolic process; one-carbon compound metabolic process; protein tetramerization; tetrahydrofolate metabolic process
Reference #:  P34897 (UniProtKB)
Alt. Names/Synonyms: GLY A+; GLYA; glycine auxotroph A, human complement for hamster; Glycine hydroxymethyltransferase; GLYM; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT2; threonine aldolase
Gene Symbols: SHMT2
Molecular weight: 55,993 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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