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EEF2 a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation elongation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; cytosol; extracellular matrix; extracellular region; membrane; nucleus; plasma membrane; ribonucleoprotein complex
Molecular Function: cadherin binding; protein binding; protein kinase binding; RNA binding
Biological Process: neutrophil degranulation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; positive regulation of translation; protein amino acid methylation; translational elongation
Disease: Spinocerebellar Ataxia 26
Reference #:  P13639 (UniProtKB)
Alt. Names/Synonyms: EEF-2; EEF2; EF-2; EF2; Elongation factor 2; eukaryotic translation elongation factor 2; polypeptidyl-tRNA translocase
Gene Symbols: EEF2
Molecular weight: 95,338 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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