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DYN1 a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: mitochondrial membrane; plasma membrane
Molecular Function: GTPase activity; identical protein binding; microtubule binding; protein binding; protein kinase binding; RNA binding
Biological Process: endocytosis; endosome organization and biogenesis; ephrin receptor signaling pathway; mitochondrial fission; receptor-mediated endocytosis
Disease: Epileptic Encephalopathy, Early Infantile, 31
Reference #:  Q05193 (UniProtKB)
Alt. Names/Synonyms: DNM; DNM1; DYN1; dynamin 1; Dynamin-1
Gene Symbols: DNM1
Molecular weight: 97,408 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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